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Glycine, Serine and Threonine Metabolism in B. melitensis

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Description

B. melitensis (Brucella melitensis) is a Gram-negative, aerobic, facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. Species in the genus Brucella are the etiological agents of Brucellosis, a zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febrile illness in humans. Brucella is facultative intracellular pathogens that enter the host through mucosal surfaces and are able to survive inside macrophages (Ref.1 & 2). The presence of S-LPS (Smooth Lipopolysaccharide) is an important virulence factor of these organisms. The role of the O-side chain or O-antigen of S-LPS in the survival of Brucella has not been clearly defined; however [...]

References:

1.Brucella melitensis review of the human infection case.
Zvizdic S, Cengic D, Bratic M, Mehanic S, Pinjo F, Hamzic S.
Bosn. J. Basic. Med. Sci. 2006 Feb;6(1):15-8.
2.Acute pancreatitis associated with brucellosis.
Papaioannides D, Korantzopoulos P, Sinapidis D, Charalabopoulos K, Akritidis N.
JOP. 2006 Jan 11;7(1):62-5.
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