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Glycine, Serine and Threonine Metabolism in B. suis

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Species in the genus Brucella are the etiological agents of Brucellosis, a zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febrile illness in humans. Brucella is facultative intracellular pathogens that enter the host through mucosal surfaces and are able to survive inside macrophages. B. suis (Brucella suis) is the first Gram-negative pathogenic organism weaponized as a potential bioterrorism agent (Ref.1). The presence of S-LPS (Smooth Lipopolysaccharide) is an important virulence factor of these organisms. The role of the O-side chain or O-antigen of S-LPS in the survival of Brucella has not been clearly defined; however it might provide a protective mechanism in Brucella to fight [...]


1.Acute pancreatitis associated with brucellosis.
Papaioannides D, Korantzopoulos P, Sinapidis D, Charalabopoulos K, Akritidis N.
JOP. 2006 Jan 11;7(1):62-5.
2.The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.
Paulsen IT, Seshadri R, Nelson KE, Eisen JA, Heidelberg JF, Read TD, Dodson RJ, Umayam L, Brinkac LM, Beanan MJ, Daugherty SC, Deboy RT, Durkin AS, Kolonay JF, Madupu R, Nelson WC, Ayodeji B, Kraul M, Shetty J, Malek J, Van Aken SE, Riedmuller S, Tettelin H, Gill SR, White O, Salzberg SL, Hoover DL, Lindler LE, Halling SM, Boyle SM, Fraser CM.
Proc. Natl. Acad. Sci. U S A. 2002 Oct 1;99(20):13148-53.
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