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Glycine, Serine and Threonine Metabolism in C. acetobutylicum

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Members of genus Clostridium are Gram-positive, spore-forming rods that are anaerobic. These bacteria includes both motile and non-motile bacillus with ubiquitous distribution in nature and are especially fond of soil. Clostridium shows optimimum growth when plated on blood agar at human body temperatures. When the environment becomes stressed, however, the bacteria produce spores that tolerate the extreme conditions that the active bacteria cannot. In their active form, these bacteria secrete powerful exotoxins that are responsible for such diseases as Tetanus, Botulism, and Gas gangrene (Ref.1). The solventogenic Clostridia like C. acetobutylicum (Clostridium acetobutylicum) continue to be the subject of numerous studies, including recent efforts to apply the tools of molecular biology and genetic engineering to alter substrate specificity and improve the efficiency [...]


1.Clostridial neurotoxins.
Goonetilleke A, Harris JB.
J. Neurol. Neurosurg. Psychiatry. 2004 Sep;75 Suppl 3:iii35-9.
2.Genomic analysis of the protein secretion systems in Clostridium acetobutylicum ATCC 824.
Desvaux M, Khan A, Scott-Tucker A, Chaudhuri RR, Pallen MJ, Henderson IR.
Biochim. Biophys. Acta. 2005 Jun 8.
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