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Glycine, Serine and Threonine Metabolism in C. albicans

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Like many bacteria, yeast species can form biofilms on several surfaces. C. albicans (Candida albicans) colonizes in the surfaces of catheters, prostheses, and epithelia, forming biofilms that are extremely resistant to anti-fungal drugs. The protein Gcn4 (Transcriptional Activator Gcn4), a regulator of amino acid metabolism, is required for normal biofilm growth. The biochemical mechanisms including activation of the sulfur-amino acid biosynthesis pathway is a feature of C. albicans biofilms. For such reasons the metabolism of Glycine, Serine and Threonine is of vital importance as it regulates morphogenesis and virulence in C. albicans. Yeasts also use L-Serine or L-Threonine as sole nitrogen source for their survival. L-Threonine is generally synthesized from Pyruvate and L-Aspartate (Ref.1 & 2). The enzymes Serine/Threonine Dehydratase [...]


1.Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns.
Garcia-Sanchez S, Aubert S, Iraqui I, Janbon G, Ghigo JM, d'Enfert C.
Eukaryot. Cell. 2004 Apr;3(2):536-45.
2.Characterization of the aspartate kinase from Saccharomyces cerevisiae and of its interaction with threonine.
Marina P, Martinez-Costa OH, Calderon IL, Aragon JJ.
Biochem. Biophys. Res. Commun. 2004 Aug 27;321(3):584-91.
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