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Glycine, Serine and Threonine Metabolism in D. vulgaris Hildenborough

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D. vulgaris (Desulfovibrio vulgaris) is a Gram-negative, anaerobic, non-spore forming, curved rod-shaped bacteria, isolated from soil, animal intestines and feces, and fresh and salt water. The distinguishing characteristics of Desulfovibrio species are that they contain Desulfoviridin, a multimeric-dissimilatory sulfite reductase. D. vulgaris Hildenborough oxidize their energy source to that of Acetate and excrete this as their end product. Desulfovibrio also uses Hydrogen, Lactate, and Pyruvate as electron donors and this genus can grow easily on a Sulfate-Lactate medium in the absence of Oxygen. The biochemical processes like metabolism of Glycine, Seine and Threonine provides Acetate, Lactate and Pyruvate by converting amino acids to Pyruvate. During metabolism L-Serine is interconverted into Pyruvate by L-Serine Dehydratase (Ref.1 & 2). Pyruvate is then [...]


1.The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.
Heidelberg JF, Seshadri R, Haveman SA, Hemme CL, Paulsen IT, Kolonay JF, Eisen JA, Ward N, Methe B, Brinkac LM, Daugherty SC, Deboy RT, Dodson RJ, Durkin AS, Madupu R, Nelson WC, Sullivan SA, Fouts D, Haft DH, Selengut J, Peterson JD, Davidsen TM, Zafar N, Zhou L, Radune D, Dimitrov G, Hance M, Tran K, Khouri H, Gill J, Utterback TR, Feldblyum TV, Wall JD, Voordouw G, Fraser CM.
Nat. Biotechnol. 2004 May;22(5):554-9.
2.Reconstruction of regulatory and metabolic pathways in metal-reducing delta-proteobacteria.
Rodionov DA, Dubchak I, Arkin A, Alm E, Gelfand MS.
Genome Biol. 2004;5(11):R90.
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