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Glycine, Serine and Threonine Metabolism in E. coli CFT073

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Description

E. coli (Escherichia coli) is Gram-negative with external flagella. The strain E. coli CFT073 are uropathogenic and this group is responsible for Acute Cystitis and Pyelonephritis. E. coli is a remarkably diverse species because some strains living as harmless commensals in animal intestines, whereas other distinct genotypes including the enteropathogenic, enterohemorrhagic, enteroinvasive, enterotoxigenic, and enteroaggregative E. coli causes significant morbidity and mortality as human intestinal pathogens (Ref.1). Extra-intestinal E. coli are another varied group of life-threatening pathogens of this manifestly versatile species. This latter group of pathogens includes distinct clonal groups responsible for neonatal meningitis/sepsis and urinary tract infections. The involvement of D- and L-Amino acid metabolism like L-Serine, D-Serine, L-Threonine and Glycine plays a major role in cell sustenance, [...]

References:

1.Mutator phenotype confers advantage in Escherichia coli chronic urinary tract infection pathogenesis.
Labat F, Pradillon O, Garry L, Peuchmaur M, Fantin B, Denamur E.
FEMS Immunol. Med. Microbiol. 2005 Jun 1;44(3):317-21.
2.Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli.
Parham NJ, Pollard SJ, Chaudhuri RR, Beatson SA, Desvaux M, Russell MA, Ruiz J, Fivian A, Vila J, Henderson IR.
J. Clin. Microbiol. 2005 May;43(5):2425-34.
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