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Glycine, Serine and Threonine Metabolism in E. coli O157 EDL933

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The bacterium E. coli O157 (Escherichia coli O157) is a worldwide threat to public health and are implicated in many outbreaks of Haemorrhagic Colitis, some of which included fatalities caused by Haemolytic Uraemic Syndrome. The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157 strains and these include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions-all of which could be targets for surveillance (Ref.1). The enterohemorrhagic E. coli O157 EDL933 is Gram-negative having external flagella. The involvement of D- and L-Amino acid metabolism like L-Serine, D-Serine, L-Threonine and Glycine plays a major role in [...]


1.Global expression of prophage genes in Escherichia coli O157:H7 strain EDL933 in response to norfloxacin.
Herold S, Siebert J, Huber A, Schmidt H.
Antimicrob. Agents Chemother. 2005 Mar;49(3):931-44.
2.Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.
Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR.
Nature. 2001 Jan 25;409(6819):529-33. Erratum in: Nature 2001 Mar 8;410(6825):240.
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