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Glycine, Serine and Threonine Metabolism in E. coli O157 Sakai

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Description

The bacterium E. coli O157 (Escherichia coli O157) is a worldwide threat to public health and are implicated in many outbreaks of Haemorrhagic Colitis, some of which included fatalities caused by Haemolytic Uraemic Syndrome. The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157 strains and these include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions-all of which could be targets for surveillance (Ref.1). The enterohemorrhagic E. coli O157 Sakai is Gram-negative, having external flagella and first derived from an outbreak in Sakai city, Japan. It produces two kinds of cytotoxins to establish hemorrhagic [...]

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