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Glycine, Serine and Threonine Metabolism in M. loti

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Description

Rhizobium, Bradyrhizobium, Mesorhizobium, Sinorhizobium, and Azorhizobium-collectively known as rhizobia, are Gram-negative, nitrogen-fixing bacteria of agronomic importance because they perform nitrogen-fixing symbioses with leguminous plants (soybean, alfalfa, beans, peas, etc). The metabolism of amino acids like Glycine is indispensable for functioning of one-carbon metabolism and for the establishment of a fully effective, nitrogen-fixing root nodule symbiosis in M. loti (Mesorhizobium loti). Glycine acts as a source of other vital amino acids like L-Serine and L-Threonine. It also contributes to the one-carbon pool, to formation of Glutathione, to Purine nucleotides, and to Porphyrins. Purine Metabolism may also form a source of Glycine. Direct routes of Glycine metabolism includes the reversible interconversions between Glycine-L-Serine and Glycine-L-Threonine, catalyzed by the PLP-dependent enzymes SHMT (Serine [...]

References:

1.Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti.
Kaneko T, Nakamura Y, Sato S, Asamizu E, Kato T, Sasamoto S, Watanabe A, Idesawa K, Ishikawa A, Kawashima K, Kimura T, Kishida Y, Kiyokawa C, Kohara M, Matsumoto M, Matsuno A, Mochizuki Y, Nakayama S, Nakazaki N, Shimpo S, Sugimoto M, Takeuchi C, Yamada M, Tabata S.
DNA Res. 2000 Dec 31;7(6):331-8.
2.Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti (supplement).
Kaneko T, Nakamura Y, Sato S, Asamizu E, Kato T, Sasamoto S, Watanabe A, Idesawa K, Ishikawa A, Kawashima K, Kimura T, Kishida Y, Kiyokawa C, Kohara M, Matsumoto M, Matsuno A, Mochizuki Y, Nakayama S, Nakazaki N, Shimpo S, Sugimoto M, Takeuchi C, Yamada M, Tabata S.
DNA Res. 2000 Dec 31;7(6):381-406.
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