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Glycine, Serine and Threonine Metabolism in S. enterica serovar Choleraesuis

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Description

Salmonella are important pathogens in humans and animals. S. choleraesuis (Salmonella enterica serovar Choleraesuis) is a highly invasive serovar among non-typhoidal Salmonella and usually cause systemic human Salmonellosis without Diarrhea and septicemic Salmonellosis and Enterocolitis in pigs (Ref.1). S. choleraesuis infections are difficult to treat because of the multidrug-resistant genes. S. choleraesuis has 151 pseudogenes, which, among the three Salmonella genomes, include the highest percentage of pseudogenes arising from the genes involved in bacterial Chemotaxis and signal-transduction pathways. These flagellated, Gram-negative bacilli utilize small peptides as nutrients, Chemoattractants, and Quorum Sensing signals, and their metabolism is a target for antibiotics. The metabolism of Glycine, Serine and Threonine is a vital source of nitrogen and carbon in Salmonella. L-Serine and Glycine [...]

References:

1.The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.
Chiu CH, Tang P, Chu C, Hu S, Bao Q, Yu J, Chou YY, Wang HS, Lee YS.
Nucleic Acids Res. 2005 Mar 21;33(5):1690-8.
2.Large drug resistance virulence plasmids of clinical isolates of Salmonella enterica serovar Choleraesuis.
Chu C, Chiu CH, Wu WY, Chu CH, Liu TP, Ou JT.
Antimicrob. Agents Chemother. 2001 Aug;45(8):2299-303.
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