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Glycine, Serine and Threonine Metabolism in S. enterica serovar Paratyphi A

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Description

S. enterica (Salmonella enterica) serovars often have a broad host range and some cause both gastrointestinal and systemic disease. S. paratyphi (Salmonella paratyphi) is part of the Enterobacteriaceae family; it is a Gram-negative motile, aerobic rod which is facultatively anaerobic. The serovar Paratyphi A or S. enterica serovar Paratyphi A is restricted to humans and causes only systemic disease (Ref.1). After entering the small intestine wall, the Salmonella invades through the lymphatic system to the lymph nodes and after a period of multiplication invades the blood stream. From there the bacteria invade the liver, gall bladder, spleen, kidney and bone marrow where it multiplies and causes infection of these organs. From here they again invade the blood stream causing secondary [...]

References:

1.Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid.
McClelland M, Sanderson KE, Clifton SW, Latreille P, Porwollik S, Sabo A, Meyer R, Bieri T, Ozersky P, McLellan M, Harkins CR, Wang C, Nguyen C, Berghoff A, Elliott G, Kohlberg S, Strong C, Du F, Carter J, Kremizki C, Layman D, Leonard S, Sun H, Fulton L, Nash W, Miner T, Minx P, Delehaunty K, Fronick C, Magrini V, Nhan M, Warren W, Florea L, Spieth J, Wilson RK.
Nat. Genet. 2004 Dec;36(12):1268-74.
2.Typhoid and paratyphoid fever.
Bhan MK, Bahl R, Bhatnagar S.
Lancet. 2005 Aug 27-Sep 2;366(9487):749-62.
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