About Us
Contact Us
Login to Protein Lounge!

Glycine, Serine and Threonine Metabolism in S. enterica serovar Typhi

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


S. typhi (Salmonella typhi) or S. enterica serovar Typhi (Salmonella enterica serovar Typhi) is the aetiological agent of Typhoid fever, a serious invasive bacterial disease of humans. Many S. enterica serovars actively invade the mucosal surface of the intestine but are normally contained in healthy individuals by the local immune defence mechanisms. However, S. typhi has the ability to spread to the deeper tissues of humans, including liver, spleen and bone marrow (Ref.1). The most studied S. enterica serovar Typhi strains are Ty2 and strain CT18. The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics. Salmonella are the [...]


1.Typhoid and paratyphoid fever.
Bhan MK, Bahl R, Bhatnagar S.
Lancet. 2005 Aug 27-Sep 2;366(9487):749-62.
2.Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.
Deng W, Liou SR, Plunkett G 3rd, Mayhew GF, Rose DJ, Burland V, Kodoyianni V, Schwartz DC, Blattner FR.
J. Bacteriol. 2003 Apr;185(7):2330-7.
You can get all the details on this pathway through subscription