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Glycine, Serine and Threonine Metabolism in S. flexneri 2457T

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Description

Shigella is pathogenic only for humans and the strains are unusual among enteric bacteria in their ability to gain access to the epithelial cell cytosol, where they replicate and spread directly into adjacent cells. It causes disease by invading the epithelium of the colon, resulting in an intense acute inflammatory response. Shigella species are Gram-negative, non-sporulating and facultative anaerobes. S. flexneri (Shigella flexneri) lacks surface structures such as flagella, fimbriae, and curli. Entry into epithelial cells occurs by an engulfment of the host cell membrane at the interaction points with bacteria. Shigella strains contain a large virulence plasmid that is known to encode genes required and sufficient for invasion of epithelial cells. Genes on a virulence plasmid encode the primary [...]

References:

1.Infections caused by Shigella flexneri recognized as food poisonings in Warmia and Mazury Voivodeship.
Sokolowska M, Ulatowska-Bogdan W, Tunowska M, Dziedziech M, Dzisko J.
Przegl. Epidemiol. 2005;59(1):53-8.
2.Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells.
Athman R, Fernandez MI, Gounon P, Sansonetti P, Louvard D, Philpott D, Robine S.
Cell Microbiol. 2005 Aug;7(8):1109-16.
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