About Us
Contact Us
Login to Protein Lounge!

Glycine, Serine and Threonine Metabolism in S. pombe

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The metabolism of Glycine, Serine and Threonine is essential for the unicellular eukaryote S. pombe (Schizosaccharomyces pombe), as it uses L-Serine or L-Threonine as sole nitrogen source for its survival. During the metabolism of these amino acids, L-Threonine is generally synthesized from Pyruvate and L-Aspartate. The enzyme Threonine Ammonia Lyase/Threonine Dehydratase converts Pyruvate (from Pyruvate metabolism) to amino acids like L-Serine. Serine Hydroxymethyltransferase/Glycine Hydroxymethyltransferase then catalyzes the THF (Tetrahydrofolate) dependent cleavage of L-Serine to Glycine and 5,10-Methylene-THF (5,10-Methylenetetrahydrofolate). Serine Hydroxymethyltransferase is the major provider of one-carbon units in the cell, which are derived from catabolism of three donor molecules like Serine, Glycine and Formate. One-carbon units are activated by attachment at various oxidation states to the carrier molecule THF. They [...]


1.A new mutation in the yeast aspartate kinase induces threonine accumulation in a temperature-regulated way.
Velasco I, Arevalo-Rodriguez M, Marina P, Calderon IL.
Yeast. 2005 Jan 30;22(2):99-110.
2.The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Dusterhoft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sanchez M, del Rey F, Benito J, Dominguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P.
Nature. 2002 Feb 21;415(6874):871-80.
You can get all the details on this pathway through subscription