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Glycine, Serine and Threonine Metabolism in S. thermophilum

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Description

S. thermophilum (Symbiobacterium thermophilum) is a Tryptophanase-positive, Gram-negative, symbiotic thermophile, which shows normal growth only in co-culture with its supporting bacteria like Bacillus sp. under both aerobic and anaerobic conditions. S. thermophilum possesses the necessary enzymes required for the biosynthesis of all essential amino acids. The metabolism of Serine and Glycine is used as a source of Glycine, Serine, one-carbon units, and Threonine. L-Serine is a key intermediate in a number of important metabolic pathways and is also an important precursor biomolecule in the synthesis of Phospholipids (Ref.1 & 2). L-Serine is converted into phospholipids like Phosphatidylserine and Phosphatidylethanolamine by Phosphatidylserine Synthase and PsD (Phosphatidylserine Decarboxylase), respectively. These membrane associated phospholipids play a critical role in the phospholipid composition of [...]

References:

1.Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.
Ueda K, Yamashita A, Ishikawa J, Shimada M, Watsuji TO, Morimura K, Ikeda H, Hattori M, Beppu T.
Nucleic Acids Res. 2004 Sep 21;32(16):4937-44.
2.Symbiobacterium thermophilum gen. nov., sp. nov., a symbiotic thermophile that depends on co-culture with a Bacillus strain for growth.
Ohno M, Shiratori H, Park MJ, Saitoh Y, Kumon Y, Yamashita N, Hirata A, Nishida H, Ueda K, Beppu T.
Int. J. Syst. Evol. Microbiol. 2000 Sep;50 Pt 5:1829-32.
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