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Glycine, Serine and Threonine Metabolism in T. denticola

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The Gram-negative oral spirochete T. denticola (Treponema denticola) is predominantly associated with the incidence and severity of human periodontal disease. T. denticola is an obligate anaerobe commonly associated with an inflammation of gum tissue that frequently precedes bone resorbtion and subsequent tooth loss of humans. T. denticola lacks a traditional LPS (Lipopolysaccharide), as do many other Spirochetes, for which these are resistant to cationic peptide antibiotics as well as to human Beta-Defensins, as these interact strongly with LPS due to its negative charge. Such a mechanism prompts T. denticola to thrive in gum tissue and affect substrate specificity and permit the utilization of amino acids and other compounds for substrate phosphorylation and ATP production. Metabolism of amino acids Glycine, Serine [...]


1.Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.
Seshadri R, Myers GS, Tettelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT.
Proc. Nat.l Acad. Sci. U S A. 2004 Apr 13;101(15):5646-51.
2.Treponema denticola is resistant to human beta-defensins.
Brissette CA, Lukehart SA.
Infect. Immun. 2002 Jul;70(7):3982-4.
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