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Glycine, Serine and Threonine Metabolism in T. maritima

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Description

T. maritima (Thermotoga maritima), is an anerobic, Gram-negative, rod-shaped bacterium which usually grows singly or in pairs. The organism has an optimum growth temperature of 80 degrees centigrade. T. maritima metabolizes many simple and complex carbohydrates, keto-acids, etc. to fuels such as Hydrogen. The metabolism of amino acids like Glycine, Serine and Threonine acts as a source of carbon and energy for T. maritima by the conversion of amino acids to keto-acids and carbohydrates (Ref.1). The Glycine Cleavage System catalyzes the oxidative decarboxylation of Glycine in bacteria to supply one carbon units and generation of other vital amino acids like L-Serine and L-Threonine. The Glycine Cleavage reaction catalyzes the oxidative cleavage of Glycine to 5,10-Methylene-THF (5,10-Methylenetetrahydrofolate), Carbondioxide and Ammonia. In [...]

References:

1.Physics and evolution of thermophilic adaptation.
Berezovsky IN, Shakhnovich EI.
Proc. Natl. Acad. Sci. U S A. 2005 Sep 6;102(36):12742-7.
2.Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia.
Lee HH, Kim do J, Ahn HJ, Ha JY, Suh SW.
J. Biol. Chem. 2004 Nov 26;279(48):50514-23.
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