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Glycine, Serine and Threonine Metabolism in T. tengcongensis

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T. tengcongensis (Thermoanaerobacter tengcongensis) is a rod-shaped, Gram-negative, anaerobic eubacterium that metabolizes sugars as the principal source of energy and carbon source, and gains energy anaerobically by Sulfur respiration. T. tengcongensis has a complete collection of genes involved in most of the amino acid biosynthetic pathways for Threonine, Valine, Leucine, Histidine, Phenylalanine/Tyrosine, Tryptophan, Arginine and Methionine. However, it lacks a few key genes such as Threonine Dehydratase for Isoleucine biosynthesis and Ornithine Cyclodeaminase for Proline biosynthesis. For nucleotide metabolism, it also has a complete set of genes for Purine biosynthesis, Purine salvage, and Pyrimidine biosynthesis pathways (Ref.1). In the direction of L-Threonine biosynthesis, Aspartokinases catalyze the ATP-dependent phosphorylation of L-Aspartate (metabolite from Aspartate Metabolism) to L-4-Aspartyl Phosphate. Next ASD (Aspartate [...]


1.A complete sequence of the T. tengcongensis genome.
Bao Q, Tian Y, Li W, Xu Z, Xuan Z, Hu S, Dong W, Yang J, Chen Y, Xue Y, Xu Y, Lai X, Huang L, Dong X, Ma Y, Ling L, Tan H, Chen R, Wang J, Yu J, Yang H.
Genome Res. 2002 May;12(5):689-700.
2.Bacterial variations on the methionine salvage pathway.
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A.
BMC. Microbiol. 2004 Mar 4;4:9.
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