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GnRH Signaling

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Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. The hypothalamic GnRH (Gonadotropin Releasing Hormone), also called LHRH (Luteinizing Hormone Releasing Hormone), is a key regulator in this system (the hypothalamic-pituitary-gonadal axis), that plays a decisive role in the neuroendocrine regulation of human reproduction. GnRH is a decapeptide, released in an episodic manner from the hypothalamic GnRH neurons. The pulsatile delivery of GnRH to the anterior pituitary gland is essential to maintain the circulating gonadotropin profiles. It acts via a specific GPCR (G-Protein Coupled Receptor): GnRHR (GnRH Receptor) and triggers the synthesis of the common Alpha- and Beta-chains of the gonadotropins, which in turn, control the function [...]


1.GnRHs and GnRH receptors.
Millar RP.
Anim Reprod Sci. 2005 Aug;88(1-2):5-28.Review.
2.GnRH in non-hypothalamic reproductive tissues.
Ramakrishnappa N, Rajamahendran R, Lin YM, Leung PC.
Anim Reprod Sci. 2005 Aug;88(1-2):95-113. Review.
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