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Guidance Cues and Growth Cone Motility

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As an axon grows, the growth cone at its advancing edge encounters specific ‘choice points’ at which guidance cues steer specific axons towards their appropriate destinations. Such cues may attract a subset of axons towards a given domain, repel axons from inappropriate target regions or simply provide a permissive substrate for axonal outgrowth. There are many different ways in which a guidance signal might intervene to steer the growth cone. For example, a guidance cue might promote the initiation, extension, stabilization, or retraction of individual filopodia, or the capture or stabilization of microtubules in specific regions of the growth cone. In each of these cases, guidance signals must be relayed through the growth cone to the actin cytoskeleton, a dynamic [...]


1.A Molecular Model for Axon Guidance Based on Crosstalk between Rho GTPases.
Sakumura Y, Tsukada Y, Yamamoto N, Ishii S.
Biophys J. 2005 May 27
2.Structures of Axon Guidance Molecules and their Neuronal Receptors.
Barton WA, Himanen JP, Antipenko A, Nikolov DB.
Adv Protein Chem. 2004; 68:65-106.
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