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HGF Pathway

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Description

HGF (Hepatocyte Growth Factor)/SF (Scatter Factor) is a mesenchymal- or stromal-derived multipotent heparan sulfate-binding and dermatan sulfate-binding pleiotropic polypeptide that mediates epithelial-mesenchymal interactions with mitogenic, motogenic and morphogenic activities towards many normal and neoplastic epithelial cells. Initially identified as a potent hepatotrophic factor responsible for vigorous regeneration of the liver, it has now become a well characterized multipotent cytokine with biological functions that reach far beyond the original identifications, operating in virtually every tissue of the body, the cellular targets being the hepatocytes and other epithelial cells, melanocytes, endothelial and haematopoietic cells (Ref.1). During embryogenesis, HGF stimulates cell proliferation (e.g. placental cytotrophoblasts), differentiation, motility and invasiveness, induces angiogenesis, is involved in haematopoiesis, chondrogenesis, and supports organogenesis and morphogenesis of various [...]

References:

1.HGF/SF-Met signaling in tumor progression.
Gao CF, Vande Woude GF.
Cell Res. 2005 Jan;15(1):49-51. Review.
2.The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal- regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.
Maroun CR, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.
Mol Cell Biol. 2000 Nov; 20(22): 8513-25.
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