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HSV1 Replication Cycle

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Description

HSV1 (Herpes Simplex Virus Type-1) is a member of the Herpes group of viruses, the Herpesviridiae, which includes the important human pathogens HSV2, CMV (Cytomegalovirus), Varicella zoster Virus, EBV (Epstein-Barr Virus), HSV6 and 7, and Kaposi s associated Herpes virus, HHV8 (Human Herpesvirus-8). Of these, HSV1 has been the most extensively studied. Human is the only natural host to HSV. The virus is spread by contact and the usual site for the implantation is skin or mucous membrane. Following an initial infection in epithelial cells, the virus spreads to neurons of sensory ganglia, where it becomes latent. The virus emerges sporadically from latency, causing recurrent mucocutaneous lesions. Reactivation of the latent genomes upon stress can lead to re-infection of the epithelial [...]

References:

1.Herpes simplex virus glycoprotein D bound to the human receptor HveA.
Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC
Mol Cell. 2001 Jul; 8(1):169-79.
2.Herpes virus entry: an update.
Spear PG, Longnecker R.
J Virol. 2003 Oct; 77(19):10179-85.
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