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HTLV1 Replication Cycle

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Description

The retroviral life cycle begins in the nucleus of an infected cell. At this stage of the life cycle the retroviral genome is a DNA element integrated into and covalently attached to the DNA of the host cell. Deltaretroviruses are complex viruses characterized by ā€œCā€-Type morphology. The most famous examples are the HTLV1 (Human T-Lymphotropic Virus-1), HTLV2 and the BLV (Bovine Leukemia Virus). HTLV1 is associated with a neurologic degenerative disorder known as TSP (Tropical Spastic Paraparesis) or, more commonly with HAM (HTLV1-Associated Myelopathy). HTLV1 spread occurs via semen, needles, breast milk and blood (Ref.1 & 2). There is no present licensed vaccine against HTLV1. Attachment of the virus occurs via SU (Surface Glycoprotein) peplomer. Attachment receptor for both HTLV1 [...]

References:

1.HTLV-1 sweet-talks its way into cells.
Overbaugh J.
Nat. Med. 2004 Jan;10(1):20-1.
2.The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV.
Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL.
Cell 2003 Nov 14;115(4):449-59.
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