Quantcast
ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Hair Growth Cycle

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The hair follicle is a three-dimensional tube, composed mainly of epithelial cells that protrude down through the epidermis and dermis of the skin, enveloping at its base the mesenchyme-derived dermal papilla. These hair follicle acts as a sensory organ and immunologic sentinel for the skin. Hairs detect mechanical stimuli above the surface of the skin, and the slightest bend in a hair activates Neuroreceptors in the follicle, relaying important sensory information to the Nervous System. The Langerhans cells (Dendritic Antigen-Presenting Cells) at the opening of the follicle detect surface pathogens and activate the immune system. The hair follicle has a complex immunologic profile, with immunologically "privileged" matrix at its base, and a complement of perifollicular macrophages, mast cells, and other [...]

References:

1.Controls of hair follicle cycling.
Stenn KS, Paus R.
Physiol Rev. 2001 Jan; 81(1):449-494.
2.In search of the "hair cycle clock": a guided tour.
Paus R, Foitzik K.
Differentiation. 2004 Dec; 72(9-10):489-511.
You can get all the details on this pathway through subscription