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Hedgehog Signaling in Drosophila

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Description

The Hh (Hedgehog) proteins are evolutionarily conserved signaling molecules that control the normal growth and patterning of diverse animals including Drosophila and humans. In flies, Hh is required for multiple developmental processes such as embryonic segment patterning, eye and appendage development. A single Drosophila Hedgehog gene has three mammalian counterparts: SHh (Sonic Hedgehog), IHh (Indian Hedgehog), and DHh (Desert Hedgehog). The Hh proteins are extracellular signaling molecules involved in embryonic patterning and organogenesis (Ref.1 & 2). In Drosophila, Hh activates the Smo (Smoothened) G-protein-coupled receptor signal transduction pathway through its reaction with the Ptc (Patched) receptor. Activation of this pathway leads to activation of CI (Cubitus Interruptus) (the Drosophila homologue of Gli (Glioma-Associated Oncogene Homolog)), which in turn up regulates Ptc, leading to down regulation of CI. Hedgehog [...]

References:

1.Hedgehog signaling in animal development: paradigms and principles.
Ingham PW, McMahon AP.
Genes Dev. 2001 Dec 1;15(23):3059-87.
2.Molecular pathways regulating pro- migratory effects of hedgehog signaling.
Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N, Izraeli S.
J. Biol. Chem. 2006 Aug 30.
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