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Hematopoiesis from Multipotent Stem Cell

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Description

Hematopoiesis is the process that generates blood cells of all lineages (Ref.1). The process of generation of blood cells begins in the early embryo and continues throughout life (Ref.2). Every day, billions of new blood cells are produced in the body, each one derived from a HSC (Hematopoietic Stem Cell). Because most mature blood stem cells have a limited life span, the ability of HSCs to perpetuate themselves through self-renewal and generate new blood cells for the lifetime of an organism is critical to sustaining life. Hematopoietic stem cells are classified into long-term, short-term and Multipotent progenitors, based on the extent of their self-renewal abilities (Ref.3). A key problem in Hematopoietic stem cell biology is how HSC self-renewal is regulated. [...]

References:

1.Lineage-specific hematopoietic growth
Kaushansky K.
N. Engl. J. Med. 2006 May 11;354(19):2034-45.
2.Cytokine receptors and hematopoietic differentiation.
Robb L.
Oncogene. 2007 Oct 15;26(47):6715-23.
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