Quantcast
ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Hematopoiesis from Pluripotent Stem Cell

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Hematopoietic Stem Cells (HSCs) have the property of self-renewal and through cell division and differentiation, form populations of progenitor cells which are committed to the main marrow cell lines; Erythroid, Granulocytic and Monocytic, Megakaryocytic and Lymphocytic. The earlier progenitor cells are multipotent but, as division and differentiation proceed, later progenitors are formed that are committed to three, two or one cell line (Ref.1 & 2). In the strictest sense depending on potency (i.e., the capacity to differentiate into specialized cell types) stem cells are either Totipotent or Pluripotent. Totipotent cells differentiate into embryonic and extraembryonic cell types, whereas, pluripotent cells are defined as the descendants of totipotent cells which differentiates into cells derived from any of the three germ layers, [...]

References:

1.Early decisions in lymphoid development.
Ye M, Graf T.
Curr. Opin. Immunol. 2007 Apr;19(2):123-8.
2.Regulation of hematopoietic stem cell self-renewal.
Reya T.
Recent Prog. Horm. Res. 2003;58:283-95.
You can get all the details on this pathway through subscription