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Hematopoiesis from Pluripotent Stem Cell

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Hematopoietic Stem Cells (HSCs) have the property of self-renewal and through cell division and differentiation, form populations of progenitor cells which are committed to the main marrow cell lines; Erythroid, Granulocytic and Monocytic, Megakaryocytic and Lymphocytic. The earlier progenitor cells are multipotent but, as division and differentiation proceed, later progenitors are formed that are committed to three, two or one cell line (Ref.1 & 2). In the strictest sense depending on potency (i.e., the capacity to differentiate into specialized cell types) stem cells are either Totipotent or Pluripotent. Totipotent cells differentiate into embryonic and extraembryonic cell types, whereas, pluripotent cells are defined as the descendants of totipotent cells which differentiates into cells derived from any of the three germ layers, [...]


1.Early decisions in lymphoid development.
Ye M, Graf T.
Curr Opin Immunol. 2007 Apr; 19(2):123-8. Epub 2007 Feb 15. Review.
2.Regulation of hematopoietic stem cell self-renewal.
Reya T.
Recent Prog Horm Res. 2003; 58:283-95. Review.
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