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Hepatic ABC Transporters

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Description

ABC (ATP-binding cassette) transporters are a large superfamily of integral membrane proteins involved in the cellular export or import of a wide variety of different substances, including ions, lipids, cyclic nucleotides, peptides, and proteins. ABC transporters are systemically classified into eight subfamilies by sequence similarity, i.e., ABCA (ABC1), ABCB (MDR/TAP), ABCC (MRP/CFTR), ABCD (ALD), ABCE (RNAseLI/OABP), ABCF (GCN20), ABCG (White) and ANSA subclass. In general, the transmembrane part of ABC transporters contains a polar channel formed by two homologous domains, each usually consisting of five (uptake transporters) or six (efflux transporters) transmembrane alpha-helices (Ref.1 & 2).

Typically, ABC proteins are relatively specific for a particular set of substrates (except ABCB1). Substrates can be amino acids, sugars, inorganic ions, peptides, proteins, lipids [...]

References:

1.ABC transporters in the balance: is there a role in multidrug resistance?(1).
Polgar O, Bates SE.
Biochem Soc Trans. 2005 Feb; 33(Pt 1):241-5.
2.[Drug resistance mediated by ABC transporters]
Yoshikawa M, Ito A, Ishikawa T, Ikegami Y.
Gan To Kagaku Ryoho. 2004 Jan; 31(1):1-6.
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