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High Osmolarity Pathway in Budding Yeast

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Description

The internal osmolarity of a growing yeast cell is maintained higher than the external osmolarity. The resulting osmotic gradient across the plasma membrane brings in water for cell expansion and creates turgor. Yeast cells are quite resistant to various types of stress including hypertonic stress. This adaptability can be traced to stress-activated signaling pathways that sense the stress condition and activate expression of proteins that resist the toxic effects of the stress and promote survival and eventual cell growth under the new conditions. In Saccharomyces cerevisiae, changes in the osmolarity of the medium have been reported to affect different signaling pathways. The best-characterized signaling system by far involves the MAPK (Mitogen-Activated Protein Kinase) Hog1, a relative of the p38 and [...]

References:

1.Osmotic stress signaling and osmoadaptation in yeasts.
Hohmann S.
Microbiol Mol Biol Rev. 2002 Jun;66(2):300-72.
2.A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.
Tatebayashi K, Takekawa M, Saito H.
EMBO J. 2003 Jul 15;22(14):3624-34.
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