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Human Embryonic Stem Cell Pluripotency

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ESCs (Embryonic Stem Cells) are Pluripotent cells capable of differentiating into any cell type of the body. Only three species of Mammals have yielded long-term cultures of self-renewing ESCs- Mice, Monkeys, and Humans. Human ESCs are derived from Blastocysts, multicellular structures originating from four cleavages of fertilized oocytes. Isolated from the ICM (Inner Cell Mass) of Blastocysts, the ESCs retain properties of self-renewal and the potential to be committed and to differentiate toward most cell lineages. They are able to spontaneously give rise to different progenies of the three embryonic layers, namely, the Ectoderm, the Mesoderm and the Endoderm. The Pluripotency of ESCs has attracted great attention for their potential use in tissue and cell therapy. However, the molecular and [...]


1.Embryonic stem cells.
Biswas A, Hutchins R.
Stem Cells Dev. 2007 Apr;16(2):213-22.
2.Human embryonic stem cells: the battle between self-renewal and differentiation.
Darr H, Benvenisty N.
Regen Med. 2006 May;1(3):317-25.
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