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IL-2 Gene Expression in Activated and Quiescent T-Cells

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Description

IL-2 (Interleukin-2) is a biological response modifier (cytokine), which stimulates the growth, proliferation and subsequent differentiation of disease-fighting blood cells, like T-Cells, B-Cells, NK (Natural Killer) cells, monocytes, macrophages, and oligodendrocytes. It is a powerful immunoregulatory lymphokine that was originally described as "T-Cell growth factor" and is secreted primarily by Antigen-activated T-Cells (Ref.1). Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. In an autocrine fashion, the Antigen-primed THC (T Helper Cell) secretes IL-2, stimulating itself as well as other neighboring Antigen-primed T-Cells to proliferate (T-Cell activation and proliferation). Growing T-cells in long term culture require IL-2 as a growth factor, and this cytokine is crucial for achieving T-cell-mediated immunity, and thus, regulation of the [...]

References:

1.Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics.`
Osinalde N, Moss H, Arrizabalaga O, Omaetxebarria MJ, Blagoev B, Zubiaga AM, Fullaondo A, Arizmendi JM, Kratchmarova I.
J Proteomics. 2011 Dec 10;75(1):177-91. Epub 2011 Jun 23.
2.Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA.
J Exp Med. 2007 Jan 22;204(1):65-71. Epub 2007 Jan 16.
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