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IL-2 Pathway

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Description

IL-2 (Interleukin-2) is a T-Cell-derived cytokine important in the regulation of growth and differentiation of T-Cells, B-Cells, natural killer cells, glioma cells, and cells of the monocyte lineage after specifically interacting with its receptors. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. IL-2 signaling is mediated by a multichain receptor complex consisting of an alpha (CD25), beta (CD122), and gamma (CD132) chain. The IL-2R (IL-2 Receptor) alpha subunit primarily increases the affinity of ligand binding and is not known to contain a signaling domain, whereas the beta and gamma subunits participate in both ligand binding and signal transduction (Ref.1). The IL-2R signaling system proceeds through at least three different pathways, which mediate the flow of mitogenic and survival-promoting [...]

References:

1.Interleukin-2: inception, impact, and implications.
Smith KA.
Science 1988 May 27;240(4856):1169-76
2.Role of NF-kappaB in the control of apoptotic and proliferative responses in IL-2-responsive T cells.
Gómez J, García-Domingo D, Martínez-A C, Rebollo A.
Front Biosci 1997 Feb 15;2:d49-60
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