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IL-4 Pathway

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IL-4 (Interleukin-4) is a T-Cell derived multifunctional cytokine with a molecular weight of approximately 15 to 19 kD that plays a critical role in the regulation of immune responses. It plays an important role in modulating the balance of TH (T Helper) cell subsets, favouring expansion of the TH2 lineage relative to TH1. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4R (IL-4Receptor) chain and the common gamma chain, resulting in a series of phosphorylation events mediated by receptor-associated kinases (Ref.1). In turn, these cause the recruitment of mediators of cell growth, of resistance to apoptosis, [...]


1.T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis.
Mirosavljevic D, Quinn JM, Elliott J, Horwood NJ, Martin TJ, Gillespie MT.
J Bone Miner Res. 2003 Jun;18(6):984-93.
2.Crystal Structure of the Interleukin-4/Receptor Chain Complex Reveals a Mosaic Binding Interface.
Thorsten Hage, Walter Sebald, and Peter Reinemer.
Cell. 1999 Apr 16;97(2):271-81.
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