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IL-6 Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


IL(Interleukin)-6 is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs including the inflammation, hematopoiesis, and oncogenesis by regulating cell growth, gene activation, proliferation, survival, and differentiation. This proteinsignals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and GP (Glycoprotein) 130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK (Janus Kinase) kinases and activation of Ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3 (Signal Transducers and Activators of Transcription-3) and SHP2 [SH2 (Src Homology-2) Domain-containing [...]


1.Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.
Ni CW, Hsieh HJ, Chao YJ, Wang DL.
Am J Physiol Cell Physiol. 2004 Sep;287(3):C771-80. Epub 2004 May 19.
2.Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
Schust J, Sperl B, Hollis A, Mayer TU, Berg T.
Chem Biol. 2006 Nov;13(11):1235-42.
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