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IL-9 Pathway

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IL-9 (Interleukin-9) is a TH2-type cytokine first described in the mouse as a potent T-Cell and mast cell growth factor. IL-9 has been reported to be a T-Cell derived cytokine with various effects on a variety of cell types associated with allergic inflammation. IL-9 has been shown to stimulate the proliferation of activated T-Cells, enhance the production of IgE from B-Cells, and promote the proliferation and differentiation of mast cells and hematopoietic progenitors. IL-9 is a member of the 4-helix bundle cytokine family, which includes cytokines such as IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, and IL-15. Human IL-9 consists of a 14kDa glycoprotein whose mature form is composed of 144 amino acids along with a signal sequence of 18 amino [...]


1.IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders.
Levitt RC, McLane MP, MacDonald D, Ferrante V, Weiss C, Zhou T, Holroyd KJ, Nicolaides NC.
J Allergy Clin Immunol 1999 May;103(5 Pt 2):S485-91.
2.MAP kinase activation by interleukin-9 in lymphoid and mast cell lines.
Demoulin JB, Louahed J, Dumoutier L, Stevens M, Renauld JC.
Oncogene 2003 Mar 27;22(12):1763-70.
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