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IP3 Pathway

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Description

IP3 (Inositol 1,4,5-triphosphate), also known as a second messenger, is a molecule that functions to transfer a chemical signal received by the cell, such as from a hormone, neurotransmitters, growth factors and hypertrophic stimuli such as AngII (Angiotensin-II), Beta-adrenergic receptor agonists, and ET1 (Endothelin-1) to various signaling networks within the cell. IP3 is known to play a crucial role in initiating and propagating these messages; however, the precise mechanism of how IP3 relates to the next element in its signaling pathway, the calcium wave, remains highly controversial. The receptors for IP3, IP3R (IP3 Receptor) constitute a family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three different receptor types have been molecularly cloned, and their genes have been classified into a [...]

References:

1.Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences.
Szlufcik K, Missiaen L, Parys JB, Callewaert G, De Smedt H.
Biol Cell. 2006 Jan;98(1):1-14.
2.Regulation of phospholipase C isozymes by ras superfamily GTPases.
Harden TK, Sondek J.
Annu Rev Pharmacol Toxicol. 2006;46:355-79.
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