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Inhibition of Angiogenesis by TSP1

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Cancer is a multistep process that includes deregulation of cell cycle, transformation, invasion of stroma, angiogenesis and metastasis. Angiogenesis is an essential component for tumor development regulated by both proangiogenic and antiangiogenic factors (Ref.1). It is a multi-step process that includes endothelial cell proliferation, migration, basement membrane degradation, and new lumen organization. Naturally occurring inhibitors of angiogenesis i.e., antiangiogenic factors are found in mammalian tissues, where they help maintain the quiescence of the normal vasculature. Thus, angiogenic inhibitors have been considered as potential anticancer drugs. TSP1 (Thrombospondin-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and curtails tumor growth (Ref.2).

Thrombospondins are a family of extracellular matrix proteins that have diverse effects on cell [...]


1.Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.
Zhang YW, Su Y, Volpert OV, Vande Woude GF.
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12718-23. Epub 2003 Oct 10.
2.Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.
Jimenez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N.
Nat Med. 2000 Jan;6(1):41-8.
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