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Inhibition of Matrix Metalloproteinases

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MPs (Metalloproteinases) play key roles in the responses of cells to their microenvironment. By effecting proteolytic degradation or activation of cell surface and ECM (Extracellular Matrix) proteins they can modulate both cell-cell and cell-ECM interactions, which influence cell differentiation, migration, proliferation and survival. Both secreted and membrane bound forms of metalloproteinases have been implicated in pericellular proteolysis, including the MMPs (Matrix Metalloproteinases), the adamalysin-like proteinases with both metalloproteinase and disintegrin-like domains (ADAMs and their counterparts that have a thrombospondin-1-like domain, ADAM-TSs) and the Astacins (Ref.1). MMPs are endopeptidases belonging to the metzincin super family, which depend on the presence of a zinc ion for their catalytic activity. The MMP family contains at least 26 known members, which are grouped according [...]


1.ECM and cell surface proteolysis: regulating cellular ecology.
Werb Z.
Cell. 1997 Nov 14; 91(4): 439-42. Review. No abstract available.
2.The ADAM gene family: surface proteins with adhesion and protease activity.
Primakoff P, Myles DG.
Trends Genet. 2000 Feb; 16(2): 83-7. Review.
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