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Insulin Receptor Pathway

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Description

Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism. Insulin elicits a diverse array of biological responses by binding to its specific receptor (Ref.1). The insulin receptor belongs to a subfamily of receptor tyrosine kinases that includes the IGF (Insulin-like Growth Factor) receptor and the IRR (Insulin Receptor-Related Receptor). These receptors are tetrameric proteins consisting of two alpha and two beta subunits that function as allosteric enzymes in which the alpha subunit inhibits the tyrosine kinase activity of the beta subunit. Insulin has diverse effects on cells including stimulation of glucose transport, gene expression and alterations of cell morphology. The hormone mediates these effects by activation of signaling pathways which utilize, i) adaptor molecules such the [...]

References:

1.Insulin signalling and the regulation of glucose and lipid metabolism.
ALAN R. SALTIEL AND C. RONALD KAHN
Nature. 2001 Dec 13;414(6865):799-806.
2.Role of binding proteins to IRS-1 in insulin signalling.
Ogawa W, Matozaki T, Kasuga M.
Mol Cell Biochem 1998 May;182(1-2):13-22.
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