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Integrin Pathway

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Adhesive interactions between cells and ECM (Extracellular Matrix) proteins play a vital role in biological processes, including cell survival, growth, differentiation, migration, inflammatory responses, platelet aggregation, tissue repair and tumor invasion (Ref.4) and perturbing this coordination can lead to events such as malignant transformation. The major groups of proteins mediating these interactions are a family of cell surface receptors known as Integrins, named for their role in integrating the intracellular cytoskeleton with the ECM. The signals from these adhesion receptors are integrated with those originating from growth factor receptors in order to organize the cytoskeleton, stimulate cell proliferation and rescue cells from matrix detachment and induced programmed cell death (Ref.1). These functions are critical in the regulation of gene expression, [...]


1.Networks and crosstalk: integrin signaling spreads.
Schwartz MA, Ginsberg MH.
Nat Cell Biol. 2002 Apr; 4(4): E65-8.
2.Signaling by integrin receptors.
Kumar CC.
Oncogene. 1998 Sep 17; 17(11 Reviews): 1365-73. Review.
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