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Interferon Pathway

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To thwart viral infection, our cells have developed a formidable and integrated defense network that comprise of innate and adaptive immune responses. In an attempt to prevent viral replication, viral dissemination or persistent viral infection of the cell, many of these protective measures actually involve the induction of programmed cell death, or apoptosis. Once the virus has invaded the cell, a host defense-mediated response is triggered which involves the induction of a family of pleiotropic cytokines known as the IFNs (Interferons) (Ref.1). These IFNs constitute a heterogeneous group of proteins and are best known for their ability to induce cellular resistance to virus infection. However, IFNs also affect many other cellular functions, such as cell growth. IFNs are classified as [...]


1.Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection.
Wong MT, Chen SS.
Cell Mol Immunol. 2016 Jan;13(1):11-35. doi: 10.1038/cmi.2014.127. Epub 2014 Dec 29. Review.
2.Interferons as biomarkers and effectors: lessons learned from animal models.
Berry CM, Hertzog PJ, Mangan NE.
Biomark Med. 2012 Apr;6(2):159-76. doi: 10.2217/BMM.12.10. Review.
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