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Interferon Pathway

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To thwart viral infection, our cells have developed a formidable and integrated defense network that comprise of innate and adaptive immune responses. In an attempt to prevent viral replication, viral dissemination or persistent viral infection of the cell, many of these protective measures actually involve the induction of programmed cell death, or apoptosis. Once the virus has invaded the cell, a host defense-mediated response is triggered which involves the induction of a family of pleiotropic cytokines known as the IFNs (Interferons) (Ref.1). These IFNs constitute a heterogeneous group of proteins and are best known for their ability to induce cellular resistance to virus infection. However, IFNs also affect many other cellular functions, such as cell growth. IFNs are classified as [...]


1.Activation of the Innate Immune Response against DENV in Normal Non-Transformed Human Fibroblasts.
Bustos-Arriaga J, García-Machorro J, León-Juárez M, García-Cordero J, Santos-Argumedo L, Flores-Romo L, Méndez-Cruz AR, Juárez-Delgado FJ, Cedillo-Barrón L.
PLoS Negl Trop Dis. 2011 Dec;5(12):e1420. Epub 2011 Dec 20.
2.The interferons: 50 years after their discovery, there is much more to learn.
Pestka S.
J Biol Chem. 2007 Jul 13;282(28):20047-51. Epub 2007 May 14.
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