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Intraepithelial Neoplasia of Pancreas

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Description

Pancreatic ductal adenocarcinoma is the most common pancreatic neoplasm and as its name suggests it arises from ductal epithelial cells of the pancreas. Other subtypes of pancreatic neoplasms include benign and malignant cystic lesions, mucin producing tumor, acinar cell carcinoma, adenosquamous carcinoma, lymphomas and sarcomas. Pancreatic ductal adenocarcinoma evolves from a progressive cascade of cellular, morphological and architectural changes from normal ductal epithelium through preneoplastic lesions termed PanIN (Pancreatic Intraepithelial Neoplasia). These PanIN lesions are in turn associated with somatic alterations in canonical oncogenes and tumor suppressor genes. The molecular pathogenesis of human pancreatic ductal adenocarcinoma involves the temporal and spatial accumulation of genetic alterations, influenced undoubtedly by environmental exposures. The alterations that occur in canonical oncogenes, tumor suppressor genes [...]

References:

1.Mutant KRAS in the initiation of pancreatic cancer.
Deramaudt T, Rustgi AK.
Biochim. Biophys. Acta. 2005 Nov 25;1756(2):97-101.
2.Alcohol and pancreatic cancer.
Go VL, Gukovskaya A, Pandol SJ.
Alcohol. 2005 Apr;35(3):205-11.
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