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Intrinsic Prothrombin Activation Pathway

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The process by which the body prevents blood loss is referred to as coagulation. Thrombin/TFIIa (Activated Factor-II) is a multifunctional serine proteinase, which serves as an essential component of the process of Blood Coagulation - the hemostatic process of greatest interest. When a blood vessel is injured, bleeding is stopped by clotting (Coagulation) factors that form a thrombus (clot) of Fibrin threads which trap platelet aggregates and other blood cells. Clotting is a mechanism used by the body to stop bleeding. Our body needs to be able to clot blood as this is the normal way bleeding is stopped to begin the healing following an injury. The first step in clotting is adhesion of platelets, which are fragments of blood [...]


1.Rethinking the coagulation cascade.
Hoffman MM, Monroe DM.
Curr Hematol Rep. 2005 Sep;4(5):391-6.
2.Platelets and thrombin generation.
Monroe DM, Hoffman M, Roberts HR.
Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1381-9. Review.
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