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LDL Oxidation in Atherogenesis

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Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the major cause of morbidity and mortality from CVD (Cardiovascular Disease) in much of the world’s population. The disease involves the formation of Plaques in arterial walls that narrow the arterial passage, restricting blood flow and increasing the risk of occlusion of blood flow by a myocardial infarction. There is now a consensus that Atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall. The Oxidative Modification hypothesis predicts LDL (Low-Density Lipoproteins) oxidation as an early event in Atherosclerosis, and oxidized LDL as one of the important contributors of Atherogenesis (Ref.1, 2 & 3).

Lipoproteins are water-soluble spherical particles that transport nonpolar [...]


1.Role of oxidative modifications in atherosclerosis.
Stocker R, Keaney JF Jr.
Physiol Rev. 2004 Oct;84(4):1381-478.
2.Lipoprotein aggregation protects human monocyte-derived macrophages from OxLDL-induced cytotoxicity.
Asmis R, Begley JG, Jelk J, Everson WV.
J Lipid Res. 2005 Jun;46(6):1124-32.
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