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Lectin Induced Complement Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Complement is a complex system containing more than 30 various glycoproteins present in serum in the form of components, factors, or other regulators and/or on the surface of different cells in the form of receptors. It is a highly sophisticated host defence system designed to destroy pathogens. Once the complement system is activated, a chain of reactions involving proteolysis and assembly occurs, resulting in destruction of the membranes of pathogens. The cascade up to the cleavage of C3 (Complement component 3), which plays a central role in the complement system, is called the activation pathway. There are three categories of complement pathway; the classical pathway, alternative pathway and lectin pathway (Ref.1).

The recently discovered lectin pathway (also called MBL pathway or [...]


1.Complement System Part II: Role in Immunity.
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT.
Front Immunol. 2015 May 26;6:257. doi: 10.3389/fimmu.2015.00257. eCollection 2015. Review.
2.The emerging role of complement lectin pathway in trypanosomatids: molecular bases in activation, genetic deficiencies, susceptibility to infection, and complement system-based therapeutics.
Evans-Osses I, de Messias-Reason I, Ramirez MI.
ScientificWorldJournal. 2013;2013:675898. doi: 10.1155/2013/675898. Epub 2013 Feb 21. Review.
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