ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Lipid Antigen Presentation by CD1

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The CD1 (Thymocyte Antigen CD1) antigen presentation system presents lipid and glycolipid antigens to effector T-Cells, which have diverse roles in Antimicrobial responses, Antitumor immunity and in regulating the balance between Tolerance and Autoimmunity. CD1, a conserved family of MHC (Major Histocompatibility Complex)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T-lymphocytes (Ref.1). The CD1 family consists of five isoforms of non-polymorphic lipid antigen-presenting molecules, which are classified into two groups: Group-I (CD1A, CD1B, CD1C, and CD1E) and Group-II (CD1D), based on similarities between nucleotide and amino acid sequences. Topologically, they resemble the classical peptide antigen-presenting MHC molecules except that the large, exclusively nonpolar and hydrophobic, antigen-binding groove of CD1 has evolved to present [...]

References:

1.CD1 assembly and the formation of CD1-antigen complexes.
Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB.
Curr Opin Immunol. 2005 Feb;17(1):88-94.
2.CD1-restricted T-cell responses and microbial infection.
Park SH, Bendelac A.
Nature. 2000 Aug 17;406(6797):788-92. Review.
You can get all the details on this pathway through subscription