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Lipid Antigen Presentation by CD1

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The CD1 (Thymocyte Antigen CD1) antigen presentation system presents lipid and glycolipid antigens to effector T-Cells, which have diverse roles in Antimicrobial responses, Antitumor immunity and in regulating the balance between Tolerance and Autoimmunity. CD1, a conserved family of MHC (Major Histocompatibility Complex)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T-lymphocytes (Ref.1). The CD1 family consists of five isoforms of non-polymorphic lipid antigen-presenting molecules, which are classified into two groups: Group-I (CD1A, CD1B, CD1C, and CD1E) and Group-II (CD1D), based on similarities between nucleotide and amino acid sequences. Topologically, they resemble the classical peptide antigen-presenting MHC molecules except that the large, exclusively nonpolar and hydrophobic, antigen-binding groove of CD1 has evolved to present [...]


1.CD1 assembly and the formation of CD1-antigen complexes.
Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB.
Curr Opin Immunol. 2005 Feb;17(1):88-94.
2.CD1-restricted T-cell responses and microbial infection.
Park SH, Bendelac A.
Nature. 2000 Aug 17;406(6797):788-92. Review.
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