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MAPK Family Pathway

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Description

Protein kinases are ubiquitous enzymes that are able to modulate the activities of other proteins by adding phosphate groups to their tyrosine, serine, or threonine amino acids (phosphorylation). MAPKs (Mitogen-Activated Protein Kinases), which are activated by many different signals, belong to a large family of serine/threonine protein kinases that are conserved in organisms as diverse as yeast and humans (Ref.1). MAPKs deliver extracellular signals from activated receptors to various cellular compartments, notably the nucleus, where they direct the execution of appropriate genetic programs, including activation of gene transcription, protein synthesis, cell cycle machinery, cell death, and differentiation. A unique feature of MAPKs is that they themselves can be activated by addition of phosphate groups to both their tyrosine and threonine [...]

References:

1.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.
Alam R, Gorska MM.
Clin Exp Allergy. 2011 Feb;41(2):149-59.
2.Mitogen activated protein kinases: a role in inflammatory bowel disease?
Broom OJ, Widjaya B, Troelsen J, Olsen J, Nielsen OH.
Clin Exp Immunol. 2009 Dec;158(3):272-80.
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