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MAPK Pathway in Fission Yeast

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Description

In both Prokaryotes and Eukaryotes, a major adaptive response to various Stress conditions is to change the repertoire of Gene expression. Prokaryotic cells commonly employ the two-component Signal Transduction Systems, where a “sensor” Histidine Kinase, often located in the Plasmamembrane, mediates environmental signals to a cytoplasmic “response regulator” that controls transcription of the target gene. Although Homologous mechanisms have been found also in some Eukaryotic organisms, recent studies have uncovered a pivotal role of MAPK (Mitogen-Activated Protein Kinase) Cascades in stress signaling of Yeast and Vertebrate cells. Each MAPK Cascade comprises a series of three or more protein kinases, each phosphorylating and thereby activating the next in line. The last Kinase of the series (the MAPK) is activated by dual [...]

References:

1.Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.
Nguyen AN, Lee A, Place W, Shiozaki K.
Mol Biol Cell. 2000 Apr;11(4):1169-81.
2.Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.
Chung KS, Won M, Lee SB, Jang YJ, Hoe KL, Kim DU, Lee JW, Kim KW, Yoo HS.
J Biol Chem. 2001 Oct 26;276(43):40190-201. Epub 2001 Jul 18. Erratum in: J Biol Chem 2002 Mar 1;277(9):7626-7.
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