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MAPK Signaling

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Intracellular signaling cascades are the main routes of communication between the Plasma membrane and regulatory targets in various intracellular compartments. Sequential activation of Kinases is a common mechanism of signal transduction in many cellular processes. During the past decade, several related intracellular signaling cascades have been elucidated, which are collectively known as MAPK (Mitogen-Activated Protein Kinase) signaling cascades. The MAPKs are a group of protein Serine/threonine Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. In combination with several other signaling pathways, they can differentially alter phosphorylation status of numerous proteins, including Transcription Factors, Cytoskeletal proteins, Kinases and other Enzymes, and greatly influence Gene Expression, Metabolism, [...]


1.Mitogen-activated protein kinases in apoptosis regulation.
Wada T, Penninger JM.
Oncogene. 2004 Apr 12;23(16):2838-49.
2.Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma.
Panka DJ, Atkins MB, Mier JW.
Clin Cancer Res. 2006 Apr 1;12(7 Pt 2):2371s-2375s.
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