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Description |
MDSCs (Myeloid-Derived Suppressor Cells) are recently been recognized as
critical mediators of tumor progression in numerous solid tumours through their
inhibition of tumor-specific immune responses. These cells are increased in
numerous pathologic conditions, including infections, inflammatory diseases,
graft-versus-host disease, traumatic stress, and neoplastic diseases. MDSCs
inhibit not only activation of T cells by anti-CD3 and super antigen, but also
antigen-specific CD4+ and CD8+ T-cell responses. The mechanisms of MDSC
immunosuppression are diverse, it includes up-regulation of ROS (Reactive Oxygen
Species), NO (Nitric Oxide), and L-Arginine metabolism. It also facilitates
tumour-induced immune suppression and tumour progression by inducing the
accumulation of immunosuppressive T-Reg (T regulatory cell) (Ref 1 &
2).
In bone marrow HPC (Hematopoietic Progenitor Cells) proliferate,
differentiate, and commit to various hematopoietic [...] |
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